201766(火)

For statistical analysis GraphPad-Prism was used

Statistical analysis
For statistical analysis GraphPad-Prism was used, testing for normality whenever sufficient replicates were available. Data were analysed by one-way or two-way ANOVA with Bonferroni or Newman–Keuls multiple comparisons tests or by t-test (Fig. 10f). Resulting P values are shown in figure legends, P<0.05 being considered significant. *<0.05, **<0.01, ***<0.001. All data shown are means±s.e.m. with ns indicated, showing variation within each group are largely similar in any one bar chart. Full statistical analysis tables not shown within the figures (Figs 4 and 5) are included as Supplementary Data File 1. Sample size was selected based on pilot studies and to be able to evaluate statistical significance (n=3 minimum; n in all cases refers to biological replicates).

Data availability
All relevant data are available from the authors on request.

Additional information
How to cite this article: Melero-Fernandez de Mera, R.M.. et al. A simple optogenetic MAPK inhibitor design reveals resonance LED Tube China between transcription-regulating circuitry and temporally-encoded inputs. Nat. Commun. 8, 15017 doi: 10.1038/ncomms15017 (2017).

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.






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