Although many studies using the fish photosensitive cells focus on circadian photopigments and the photic input pathway14,15,16,17,18,19,20,21,22,23,24,25,26, the specificity and generality of the photic gene regulation mechanism in lower vertebrates remains unclear. This is partly due to the high differentiation of systems within a single species. For example, even among the zebrafish photosensitive clock cell lines, the zPer2 gene is induced by blue Vintage Edison Bulbbut not red light in Z3 cells15, while it is induced by both blue and red light in PAC-2 cells25. Another reason for the lack of clarity may be the concentration of studies on zebrafish cells and the lack of a model cell line that originates from different species. In particular, the teleost species have a diverging repertoire of circadian clock genes due to lineage-specific gene duplications and differential gene deletions27. Therefore, we considered the search for another suitable fish cell line important for comparative analyses of the photoresponses and clock mechanisms across species.