2017年6月7日（水）
Road Runner High-Speed Online
Road Runner High-Speed Online Internet Service Offers The Best Download Speeds And Online Experience
The Time Warner Cable company that provides all your other great services will also provide you with Road Runner Internet service. Along with the great internet access comes great support. You can get a customizable home page, more email accounts and the most reliable Internet service when you switch your ISP to Road Runner. Add to this the speed with Time Warner CCTV coaxial cable Internet and you will be more than happy. Unlike with dial-up, the connection remains on at all times so there is no waiting to get onto the internet. The Internet is right there and ready; you need do nothing more than start surfing. A family that spends a lot of time online will benefit from the lack of extra charges. |Getting the whole family online is now even easier with the free wireless router from Time Warner Cable.
The Time Warner Cable company that provides all your other great services will also provide you with Road Runner Internet service. Along with the great internet access comes great support. You can get a customizable home page, more email accounts and the most reliable Internet service when you switch your ISP to Road Runner. Add to this the speed with Time Warner CCTV coaxial cable Internet and you will be more than happy. Unlike with dial-up, the connection remains on at all times so there is no waiting to get onto the internet. The Internet is right there and ready; you need do nothing more than start surfing. A family that spends a lot of time online will benefit from the lack of extra charges. |Getting the whole family online is now even easier with the free wireless router from Time Warner Cable.
2017年6月7日（水）
Some of the examples of plug-in devices
Comcast has been providing hzspring TV for years. Now, Comcast is not just the company of choice for digital cable, but also for broadband internet and unlimited phone service. Comcast is the leader in providing bundled services and can meet your needs for home telephone, high speed Internet, and cable television services. Comcast is the largest cable company in the US, and the best choice for your telephone, cable, and Internet needs.Multiple Ports Give You Usage With The Four Port Usb Cable | A Mobile Article
Here is a four in one equipment that will connect the four external devices all together in one computer and that too at the same time. The USB Hub Cable with Four Port USB Cable allows you to connect up to four peripheral devices. These peripheral devices should be of plug-in nature to make it work better. Some of the examples of plug-in devices include keyboards, mouse, scanners, printers and digital cameras. These too can be connected to the USB Hub Cable with Four Port USB Cable. It thus allows the user to do multiple tasks at a time because of the availability of maximum four peripheral devices at the same time.
Here is a four in one equipment that will connect the four external devices all together in one computer and that too at the same time. The USB Hub Cable with Four Port USB Cable allows you to connect up to four peripheral devices. These peripheral devices should be of plug-in nature to make it work better. Some of the examples of plug-in devices include keyboards, mouse, scanners, printers and digital cameras. These too can be connected to the USB Hub Cable with Four Port USB Cable. It thus allows the user to do multiple tasks at a time because of the availability of maximum four peripheral devices at the same time.
2017年6月6日（火）
People have a tendency to accumulate cable
Take out your most recent bill and study it carefully. You will likely see a list of itemized charges. Look at each charge carefully. Do you what the charge is for? Is the price listed accurately? If you are writing the cable company a check every month, you at least ought to know where your money is going. If you are not sure what a charge is for, do a quick Google search to see if you can find out. If you cannot find anything online, then it might be necessary to call the company to clarify. Of course, if you are being overcharged for a service, you will need to call the company to remedy the situation. It is extremely important to examine your bill! If you never bother to look, you will never know if you are being overcharged.
People have a tendency to accumulate cable and internet services. Perhaps when you signed up for services there was a special deal that included digital video recording (DVR) or premium cable channels (HBO, Showtime, etc.). Perhaps at some point in your life you added an extra sports package or upgraded your internet service. Take the time to scrutinize your cable and internet package. Do you really need everything that you are paying for? How often do you use the DVR? How often do you watch the premium channels? Could you get by with fewer cable channels or a slower internet connection? Take a long, hard look at everything and drop what you do not need. Remember that even a small change can mean big savings over the course of a year. Dropping DVR services that you rarely use could save you $12 a month, or $144 a year.
People have a tendency to accumulate cable and internet services. Perhaps when you signed up for services there was a special deal that included digital video recording (DVR) or premium cable channels (HBO, Showtime, etc.). Perhaps at some point in your life you added an extra sports package or upgraded your internet service. Take the time to scrutinize your cable and internet package. Do you really need everything that you are paying for? How often do you use the DVR? How often do you watch the premium channels? Could you get by with fewer cable channels or a slower internet connection? Take a long, hard look at everything and drop what you do not need. Remember that even a small change can mean big savings over the course of a year. Dropping DVR services that you rarely use could save you $12 a month, or $144 a year.
2017年6月6日（火）
Molecular dynamics simulation of OptoJNKi
This simulation shows the C-terminal phenylalanine participating in van der Waals interactions with residues (coloured in forest green, Fig. 9a,b) P420, R421 (β/γ carbons, not the guanidinium), D505, V506, F509. These create a stable ‘packed’ structure by ‘caging’ the phenylalanine and shielding it from the solvent. L546 is more fully caged within LOV2 than F559 (C-terminal residue of OptoJNKi, Fig. 1d), and participates in van der Waals interactions with residues (in cyan, Fig. 9a,c) R549, Y508, I417 and F429 in the proximal hydrophobic pocket. Thus, our molecular dynamics simulation is consistent with OptoJNKi.L546 residing, as in wild-type AsLOV2Jα52, in the proximal Bβ/Iβ pocket which is important for regulation of the peptides interwoven into the Jα-helix, peptides SsrAC and iLID7,9. The OptoJNKi C-terminal phenylalanine remains in a distal hydrophobic pocket involving Iβ- and A/B-loop residues over the entire simulation time (10?ns), suggesting this interaction constrains movement of the JBD peptide (Fig. 9a).
Figure 9: Molecular dynamics simulation of OptoJNKi suggests a potential photoregulation mechanism by hydrophobic tether capture in a new pocket.
Figure 9
(a) Representation of the OptoJNKi structure deduced from time-averaged atom positions from a molecular dynamics simulation (see ‘Methods’ section). The Cα chain is shown in tan. The structure is overlaid with a semi-transparent molecular surface. The atoms of F559 (the C terminus of the protein) and L546, together with interacting neighbouring residues, are LED Tube China green and cyan (carbon), respectively. Regions surrounding F559 and L546 are encircled. (b) The molecular packing of the terminal phenylalanine residue into a distal hydrophobic pocket in the OptoJNKi structure, as deduced by molecular dynamics simulation, is shown. Atoms shown are coloured tan (carbon), white (hydrogen), blue (nitrogen) and red (oxygen). F559 atoms are highlighted green (carbon), as are its interacting neighbouring residues, P420, R421, D505, V506 and F509. The overlaid semi-transparent molecular surface emphasizes (i) the hydrophobic pocket of the F559, (ii) the partial ‘caging’ of F559 depicted in stick format and (iii) the depth of the hydrophobic pocket created by F559 (which is itself not shown in biii to assist in visualization). (c) The corresponding molecular packing of the L546 residue into the Jα-proximal hydrophobic pocket in the optoJNKi structure as in b is shown. L546 atoms are highlighted cyan (carbon), as are its interacting neighbouring residues R549, Y508, I417 and F429. The overlaid semi-transparent molecular surface here emphasizes the hydrophobic pocket, full ‘caging’ depth of the hydrophobic pocket created by L546 in (i)–(iii) as for F559 in Fig. 9b. (d) GST-JNK1 pulldown was performed as in Fig. 1 using the OptoJNKi (dsm and lsm) with a wide-type LOV2 pocket, the OptoJNKi (dsm and lsm) with LOV2 pocket mutant F509R, and the constitutive JBD (JIP1-277) as positive control. F509R mutants interacted with JNK1 similarly as wild-type OptoJNKi.lsm (I539E), failing to show any difference between lit- and dark-state mutants (n=3). Mean±s.e.m. is indicated, ns not significant, ***P<0.001. Analysis was carried out using by one-way ANOVA/Bonferroni post-test (Supplementary Data 1).
Full size image
Figure 9: Molecular dynamics simulation of OptoJNKi suggests a potential photoregulation mechanism by hydrophobic tether capture in a new pocket.
Figure 9
(a) Representation of the OptoJNKi structure deduced from time-averaged atom positions from a molecular dynamics simulation (see ‘Methods’ section). The Cα chain is shown in tan. The structure is overlaid with a semi-transparent molecular surface. The atoms of F559 (the C terminus of the protein) and L546, together with interacting neighbouring residues, are LED Tube China green and cyan (carbon), respectively. Regions surrounding F559 and L546 are encircled. (b) The molecular packing of the terminal phenylalanine residue into a distal hydrophobic pocket in the OptoJNKi structure, as deduced by molecular dynamics simulation, is shown. Atoms shown are coloured tan (carbon), white (hydrogen), blue (nitrogen) and red (oxygen). F559 atoms are highlighted green (carbon), as are its interacting neighbouring residues, P420, R421, D505, V506 and F509. The overlaid semi-transparent molecular surface emphasizes (i) the hydrophobic pocket of the F559, (ii) the partial ‘caging’ of F559 depicted in stick format and (iii) the depth of the hydrophobic pocket created by F559 (which is itself not shown in biii to assist in visualization). (c) The corresponding molecular packing of the L546 residue into the Jα-proximal hydrophobic pocket in the optoJNKi structure as in b is shown. L546 atoms are highlighted cyan (carbon), as are its interacting neighbouring residues R549, Y508, I417 and F429. The overlaid semi-transparent molecular surface here emphasizes the hydrophobic pocket, full ‘caging’ depth of the hydrophobic pocket created by L546 in (i)–(iii) as for F559 in Fig. 9b. (d) GST-JNK1 pulldown was performed as in Fig. 1 using the OptoJNKi (dsm and lsm) with a wide-type LOV2 pocket, the OptoJNKi (dsm and lsm) with LOV2 pocket mutant F509R, and the constitutive JBD (JIP1-277) as positive control. F509R mutants interacted with JNK1 similarly as wild-type OptoJNKi.lsm (I539E), failing to show any difference between lit- and dark-state mutants (n=3). Mean±s.e.m. is indicated, ns not significant, ***P<0.001. Analysis was carried out using by one-way ANOVA/Bonferroni post-test (Supplementary Data 1).
Full size image
2017年6月6日（火）
Cavitation volume and Euler number
Figure 6 shows the cavitation volume Vc in terms of the inverse Euler number , a dimensionless number that is independent of the viscosity of the system. The ratio between the pressure gradient and the kinetic energy per volume is decisive for the development of a cavitating volume, as captured distinctly in Fig. 6. Independent of the model system cavitation occurs at the same Euler number . When cavitation first occurs in the experiments we find that is within similar order of magnitude as the simulations.
Dependence of the cavitation volume on the inverse Euler number for the nematic LC (red circle) and isotropic LC (blue square).
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Figure 7 maps the local nematic order parameter over the range of flow regimes considered here. The flow field reorients the nematic director from homeotropic (on the surfaces) to flow-aligned orientation (in the flowing matrix). Topological defects arise in the director field, close to the top and the bottom walls, where the cylindrical pillar intersects the channel surfaces (Fig. 7a). The singular defect loops are formed due to the homeotropic anchoring, both on the channel surfaces and on the pillar, and are consistent with the defect topology discussed in ref. 49. It is evident from Fig. 7d that over the x–y plane, located at the channel half depth (z=0), no defect is visible. The director field remains stable for small Er. However, for Er≥675 a single loop around the pillar stabilizes in the x–y mid-plane. The loop is deformed and extended towards the downstream direction along with the flow, shown in Fig. 7b,e. Additionally, there is a growing region of flow alignment behind the cylindrical pillar in the downstream T5 Fluorescent Lamp direction. Upon increasing Er one can see that the loop becomes stretched further downstream (see Fig. 7c). However, the overall defect topology, especially downstream behind the pillar, is increasingly smeared, possibly due to the appearance of the vapour phase at high Ericksen numbers (Fig. 7f). Changing the surface anchoring from homeotropic to planar did not produce any qualitative change in our results. This agrees well with the experiments, where too we have observed that cavitation in nematic phase was independent of the nature of the surface anchoring.
Dependence of the cavitation volume on the inverse Euler number for the nematic LC (red circle) and isotropic LC (blue square).
Full size image
Figure 7 maps the local nematic order parameter over the range of flow regimes considered here. The flow field reorients the nematic director from homeotropic (on the surfaces) to flow-aligned orientation (in the flowing matrix). Topological defects arise in the director field, close to the top and the bottom walls, where the cylindrical pillar intersects the channel surfaces (Fig. 7a). The singular defect loops are formed due to the homeotropic anchoring, both on the channel surfaces and on the pillar, and are consistent with the defect topology discussed in ref. 49. It is evident from Fig. 7d that over the x–y plane, located at the channel half depth (z=0), no defect is visible. The director field remains stable for small Er. However, for Er≥675 a single loop around the pillar stabilizes in the x–y mid-plane. The loop is deformed and extended towards the downstream direction along with the flow, shown in Fig. 7b,e. Additionally, there is a growing region of flow alignment behind the cylindrical pillar in the downstream T5 Fluorescent Lamp direction. Upon increasing Er one can see that the loop becomes stretched further downstream (see Fig. 7c). However, the overall defect topology, especially downstream behind the pillar, is increasingly smeared, possibly due to the appearance of the vapour phase at high Ericksen numbers (Fig. 7f). Changing the surface anchoring from homeotropic to planar did not produce any qualitative change in our results. This agrees well with the experiments, where too we have observed that cavitation in nematic phase was independent of the nature of the surface anchoring.
