Build your own tour: If you’re slightly deranged or a professional food writer, you’ll spend Friday touring Pierce County’s locally owned doughnut bakeries. Here’s a list of all 14:VTake the dough from the fridge about 10 minutes before you wish to roll. Cut the doughinto manageable pieces that will fit in your Automatic Cake Making Machine.Roll out on the largest setting twice, in between each roll you can sprinkle the semolina to prevent sticking as needed.

On the other hand, Dennis and co-author Paul C. Norris, a graduatestudent in the chemistry and biochemistry department and themolecular pharmacology training program, discovered that omega-3oils do not inhibit another group of enzymes called lipoxygenases(LOX), which are also produced by stimulated macrophages. One typeof generated LOX enzyme in turn produces fat-signaling moleculescalled leukotrienes, which are pro-inflammatory.

But Norris notedthat LOX enzymes may also generate anti-inflammatory compoundscalled resolvins from EPA and DHA. These observations, he said, are also helpful in identifyingpotential adverse effects from taking fish oil. Since omega-3 fattyacids possess overlapping functions with COX inhibitor drugs, withwell-known side effects, using both in combination can produceunexpected consequences.

It is this parsing of what's happening inside cells that Denniscalled "ground-breaking." "We've been able to look inside a cell, see what fish oils do anddetermine that the process of inflammation at this level may bemanipulatable," he said.For the first time, researchers at the University of California,San Diego have peered inside a living mouse cell and mapped theprocesses that power the celebrated health benefits of omega-3fatty acids.